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Sunday, April 19, 2020 | History

3 edition of S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease found in the catalog.

S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease

S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease

  • 279 Want to read
  • 39 Currently reading

Published by Agency for Healthcare Research and Quality in Rockville, Md .
Written in English

    Subjects:
  • S-Adenosylmethionine,
  • Depression -- drug therapy,
  • Osteoarthritis -- drug therapy,
  • Liver Diseases -- drug therapy,
  • Evidence-Based Medicine -- methods

  • Edition Notes

    StatementPrepared for Agency for Healthcare Research and Quality ; prepared by Southern California Evidence-Based Practice Center ; Mary Hardy, principal investigator ; Ian Coulter ... [et. al.], investigators.
    SeriesEvidence report/technology assessment -- no. 64, AHRQ publication -- no. 02-E034, AHRQ publication -- no. 02-E034, AHRQ publication -- no. 02-E034.
    ContributionsHardy, Mary L., Southern California Evidence-Based Practice Center/RAND., United States. Agency for Healthcare Research and Quality.
    The Physical Object
    Paginationix, 198 p. ;
    Number of Pages198
    ID Numbers
    Open LibraryOL14755433M
    ISBN 101587631229
    OCLC/WorldCa51317717


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S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease Download PDF EPUB FB2

The objective of this report was to conduct a search of the published literature on the use of S-adenosyl-L-methionine (SAMe) for the treatment of osteoarthritis, depression, and liver disease; and, on the basis of that search, to evaluate the evidence for the efficacy of by: S-Adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews Your browsing activity is empty.

Activity recording is turned by: S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver by: S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.

Hardy ML, Coulter I, Morton SC, Favreau J, Venuturupalli S, Chiappelli F, Rossi F, Orshansky G, Jungvig LK, Roth EA, Suttorp MJ, Shekelle P. Comment in ACP J Club.

Jul-Aug;(1) PMCID: PMC PMID: [Indexed for MEDLINE] Publication Types:Cited by: adenosyl-L-methionine (SAMe) for the treatment of osteoarthritis, depression, and liver disease; and, on the basis of that search, to evaluate the evidence for the efficacy of SAMe.

A broad search revealed sufficient literature to support a detailed review of the use of SAMe for three conditions: depression, osteoarthritis, and cholestasis of pregnancy and intrahepatic.

S-adenosyl-L-methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Published in: Evidence Report/Technology Assessment No. 64 (Prepared by Southern California/RAND Evidence-Based Practice Center, under Contract No. AHRQ Publication No.

ECited by: It has been well established that S-adenosyl-L-methionine (SAMe) is the principal methyl donor in methyltransferase reactions and that SAMe supplementation restores hepatic glutathione (GSH) deposits and attenuates liver injury.

However, the effectiveness of SAMe therapy in chronic liver disease has not been adequately addressed. Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease." Natural Medicines Comprehensive Database web site.

Frezza M, Pozzato G, Chiesa L, Stramentinoli G, di Padova C: Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine. Hepatology ; 4: Giannuoli G, Tine' F, Malizia G, Saracco G, Verme G, Pagliaro L: S-Adenosylmethionine for treatment of pruritus in compensated chronic liver by: Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease." Natural And liver disease book Comprehensive Database web site.

Purohit V, Russo D. Role of S-adenosyl-L-methionine in the treatment osteoarthritis alcoholic liver disease: introduction and summary of the symposium.

Alcohol. Jul;27(3) Bardag-Gorce F, Oliva J, Wong W, et al. S-adenosylmethionine decreases the peak blood alcohol levels 3h after an acute bolus of ethanol by inducing alcohol metabolizing.

Role of S‐adenosyl‐L‐methionine in liver health and injury Inthe Cochrane Hepato‐Biliary Group analyzed 8 clinical trials of SAMe treatment of alcoholic liver disease in patients.

46 This meta‐analysis found SAMe decreased total mortality (OR95% CI ‐) and liver‐related mortality Cited by: Inthe US government published a comprehensive report entitled “S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease.”1 The report represents a distillation of data gleaned from numerous published studies conducted around the world through To perform a comprehensive literature review and synthesis of evidence on the use of S-adenosyl-L-methionine (SAMe) for the treatment of depression, osteoarthritis and liver disease.

Searching Five extensive searches were conducted of 25 named databases using a search strategy that was provided in an appendix to the review.

Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal.

S-adenosylmethionine (also known as SAMe) is a manmade form of a chemical that occurs naturally in the body. SAMe has been used in alternative medicine as a likely effective aid in reducing the 5/5. Depression is a recurrent illness with high rates of chronicity, treatment-resistance and significant economic impact.

There is evidence in the literature that S-adenosyl methionine (SAMe), a naturally occurring compound in the human body, has antidepressant product may be an important addition to the armamentarium of antidepressant.

S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body.

SAMe is sold in the United States as a dietary supplement. SAMe was discovered in the early s. Several studies have evaluated the consequences of SAM supplementation to treat diseases such as depression, Alzheimer's disease, tauopathy, liver disease Author: George I.

Papakostas. Depression S-Adenosyl Methionine is used for the treatment of depression characterized by loss of interest in daily activities, emotional distress, anxiety, changes in mood, etc. Osteoarthritis S-Adenosyl Methionine is used in the treatment of osteoarthritis characterized by joint pain, stiffness, tenderness, etc.

S-adenosylmethionine (also known as SAMe) is a manmade form of a chemical that occurs naturally in the body. SAMe has been used in alternative medicine as a likely effective aid in reducing the symptoms of depression, and in treating osteoarthritis.

SAMe is possibly effective in treating liver disease during pregnancy, improving symptoms in people with / Additional Physical Format: Print version: S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease (OCoLC) Get this from a library.

S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. [United States. Agency for Healthcare Research and Quality,; Southern California Evidence-Based Practice Center/RAND,;].

Hardy ML, Coulter I, Morton SC, et al. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evid Rep Technol Assess (Summ) ;(64) View abstract. Ideo G. [S-Adenosylmethionine: plasma levels in hepatic cirrhosis and preliminary results of its clinical use in hepatology.

Double-blind study]. Depression. While research has shown that SAMe has a positive effect in treating depression, most studies weren't well-designed and included a small number of people. Liver disease. It's not clear if SAMe is beneficial for people who have liver disease. Osteoarthritis. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease [electronic resource].

S-Adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for Cited by: Several studies show that SAMe helps relieve the pain of osteoarthritis.

Other studies suggest that SAMe may help treat depression. Researchers have also examined SAMe's use in the treatment of fibromyalgia and liver disease with mixed results.

Many of the early studies used SAMe given intravenously or as an injection. ABSTRACT. S-Adenosyl-l-methionine (SAMe) exerts many key functions in the liver, including serving as a precursor for cysteine, 1 of 3 amino acids of glutathione—the major physiologic defense mechanism against oxidative is particularly important in opposing the toxicity of free oxygen radicals generated by various pathogens, including Cited by: S-Adenosyl-L-methionine (SAMe) exerts many key functions in the liver, including serving as a precursor for cysteine, 1 of 3 amino acids of glutathione-the.

S-Adenosyl-L-methionine (SAMe) is a naturally occurring molecule distributed to virtually all body tissues and fluids. It is of fundamental importance in a number of biochemical reactions involving enzymatic transmethylation, contributing to the synthesis, activation and/or metabolism of such compounds as hormones, neurotransmitters, nucleic acids, proteins, Cited by: S-adenosyl-L-methionine for Treatment of Depression, Osteoarthritis, and Liver Disease (Book).

S-Adenosyl methionine [alternative names 1] is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver.

More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids CAS Number: Personal experience with mg/day S-adenosyl-L-methionine (SAMe) divided into two i.v.

doses in the management of depression of varying aetiology in. : Same for Dogs - S-Adenosyl-l-Methionine, Same LQPromotes Cognitive Brain Support and Natural Hepatic Liver Health, Natural Chew-able Tablets.: Pet Supplies SAMe is great in the treatment of osteoarthritis, because it not only reduces inflammation and pain but also helps regenerate joint tissue.

Vet did tell me he /5(). What is S-Adenosyl Methionine or SAMe. S-adenosyl methionine or SAMe, for short, is a common dietary supplement ingredient found in products with potential benefits for improving quality of mood, promoting liver health, in addition to potentially relieving symptoms of osteoarthritis or joint pain.

It also has potential benefits in relieving symptoms of fibromyalgia. Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside-molecular basis of a pleiotrophic molecule.

Am J Clin Nutr. ;76(5)SS. Lu SC, Mato JM. S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. ;(23, suppl 1):SS Mudd SH, Poole JR. SAMe participates in many critical metabolic functions by donating methyl groups to other molecules.

Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein function. S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Accessed May /5(17). S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease.

Safe, effective support for mood and more Hcy methyltransferase [S-adenosyl-L-methionine: L-Hcy S-methyltransferase] catalyzes the direct transfer of the methyl group of either S-adenosyl-L-methionine or S-methyl-L-methionine (L-methionine.